14
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12165 | nAChR agonist 1 | DUN71755 | AChR |
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. | |||
T62317 | α7 nAchR-JAK2-STAT3 agonist 1 | ||
α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β... | |||
T16563L | Pozanicline hydrochloride | AChR | |
Pozanicline hydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline hydrochloride is an α4β2-selective nAChR agonist... | |||
T61348 | Bradanicline | ||
Bradanicline is a potent and highly selective agonist of the α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 17 nM and a Ki of 1.4 nM for the human α7 nAChR. It is primarily employed in research pertaining to... | |||
T9450 | NS3861 fumarate | ||
NS3861 fumarate is an agonist of nicotinic acetylcholine receptors (nAChRs). NS3861 fumarate is a partial agonist at α3β4 nAChR and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7... | |||
T74394 | Flupyradifurone | ||
Flupyradifurone, a systemic nicotinic acetylcholine receptor (nAChR) agonist, disrupts signal transduction within the central nervous system of sucking pests, functioning as a butenolide insecticide [1]. | |||
T74086 | 5-AMAM-2-CP | ||
5-AMAM-2-CP, a significant metabolite of Acetamiprid, serves as a global insecticide within the neonicotinoid class and acts as an nAChR agonist [1] [2]. | |||
T74130 | Epiboxidine | ||
Epiboxidine, a methylisoxazole analog of the alkaloid Epibatidine and analog of the nAChR agonist ABT 418 [1], serves as a potent and selective agonist for neural nicotinic acetylcholine receptors (nAChR), exhibiting Ki ... | |||
T4246L | Varenicline | ||
Varenicline (CP 526555), a cytisine-based nicotinic ligand, is a potent partial agonist for the α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM and acts as a full agonist for α7 and α3β4 nAChRs... | |||
T74131 | Epiboxidine hydrochloride | ||
Epiboxidine hydrochloride, a methylisoxazole analog of the alkaloid Epibatidine and an analog of the nAChR agonist ABT 418 [1], serves as a potent and selective agonist of neural nAChRs, demonstrating K i values of 0.46 ... | |||
T60437 | PNU-282987 free base | ||
PNU-282987 (free base) is a potent agonist of α7 nicotinic acetylcholine receptor (nAChR) with an EC50 of 154 nM, which is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base... | |||
T80471 | α-Conotoxin MrIC | ||
α-Conotoxin MrIC is a biased agonist selective for the α7 nicotinic acetylcholine receptor (nAChR), with activation contingent upon the presence of type II positive allosteric modulators, such as PNU120596. It is utilize... | |||
T21857 | AR-R 17779 hydrochloride | ||
AR-R17779 hydrochloride is a potent, selective full agonist of the nAChR, demonstrating K i values of 92 nM for the α7 subtype and 16,000 nM for the α4β2 subtype. It is noted for its ability to enhance learning and memor... | |||
T12738 | Rivanicline hemioxalate | RJR-2403 hemioxalate,(E)-Metanicotine hemioxalate | Others |
Rivanicline hemioxalate, also known as RJR-2403 hemioxalate or (E)-Metanicotine hemioxalate, is a chemical compound acting as a neuronal nicotinic receptor agonist with pronounced selectivity for the α4β2 receptor subtyp... |